3 ms·

Please don't post conjecture like this that has been categorically shown to be untrue. Vaccines are effective and have been shown to decrease infection and seri

Please don't post conjecture like this that has been categorically shown to be untrue. Vaccines are effective and have been shown to decrease infection and serious illness rates.

rubatuga 5y ago
You think you’re fighting misinformation, but GP could be right in terms of T cell response.
- criticaltinker 5y ago
  Vaccination has been shown to induce an immune response including T cells [1]. However, vaccination induces a slightly different immune response compared to natural infection [2][3] . These differences may account for variation in effectiveness between vaccine-induced and naturally acquired immunity. [1] Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immune responses to SARS-CoV-2 mRNA vaccination https://www.cell.com/immunity/fulltext/S1074-7613(21)00308-3 https://www.cell.com/immunity/fulltext/S1074-7613(21)00308-3 [2] Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection https://pubmed.ncbi.nlm.nih.gov/34103407/ https://pubmed.ncbi.nlm.nih.gov/34103407/ [3] mRNA vaccination compared to infection elicits an IgG-predominant response with greater SARS-CoV-2 specificity and similar decrease in variant spike recognition https://www.medrxiv.org/content/medrxiv/early/2021/04/07/2021.04.05.21254952.full.pdf https://www.medrxiv.org/content/medrxiv/early/2021/04/07/202...
  - jonny_eh 5y ago
    > differences may account for variation in effectiveness between vaccine-induced and naturally acquired immunity. What's the variation you are referring to?
    - inter_netuser 5y ago
      antibodies produced in a primary infection target a lot more than spike protein, in some pre-prints. It's all preliminary data. However, the sinopharm vaccine, which is the whole virus, not just spike protein, seems to lose effectiveness after several months as well.
- aeternum 5y ago
  Then GP should have posted some evidence. It's lazy and hinders discourse to post a conjecture that can be quickly disproved with a quick search.
eplanit 5y ago
It's not conjecture[1] -- what is misinformation is the assertion "...has been categorically shown to be untrue". Citation? I find that when people use "categorically" in an assertion (denial), then there's good reason for doubt. 1. https://www.forbes.com/sites/roberthart/2021/08/25/vaccine-protection-wanes-within-six-months-of-second-covid-shot-study-warns-but-theyre-still-effective-against-delta/?sh=7098eb6e5a80 https://www.forbes.com/sites/roberthart/2021/08/25/vaccine-p...

Please don't post conjecture like this that has been categorically shown to be untrue. Vaccines are effective and have been shown to decrease infection and serious illness rates.

rubatuga 5y ago

You think you’re fighting misinformation, but GP could be right in terms of T cell response.

criticaltinker 5y ago
Vaccination has been shown to induce an immune response including T cells [1]. However, vaccination induces a slightly different immune response compared to natural infection [2][3] . These differences may account for variation in effectiveness between vaccine-induced and naturally acquired immunity. [1] Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immune responses to SARS-CoV-2 mRNA vaccination https://www.cell.com/immunity/fulltext/S1074-7613(21)00308-3 https://www.cell.com/immunity/fulltext/S1074-7613(21)00308-3 [2] Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection https://pubmed.ncbi.nlm.nih.gov/34103407/ https://pubmed.ncbi.nlm.nih.gov/34103407/ [3] mRNA vaccination compared to infection elicits an IgG-predominant response with greater SARS-CoV-2 specificity and similar decrease in variant spike recognition https://www.medrxiv.org/content/medrxiv/early/2021/04/07/2021.04.05.21254952.full.pdf https://www.medrxiv.org/content/medrxiv/early/2021/04/07/202...
- jonny_eh 5y ago
  > differences may account for variation in effectiveness between vaccine-induced and naturally acquired immunity. What's the variation you are referring to?
  - inter_netuser 5y ago
    antibodies produced in a primary infection target a lot more than spike protein, in some pre-prints. It's all preliminary data. However, the sinopharm vaccine, which is the whole virus, not just spike protein, seems to lose effectiveness after several months as well.
aeternum 5y ago
Then GP should have posted some evidence. It's lazy and hinders discourse to post a conjecture that can be quickly disproved with a quick search.

eplanit 5y ago

It's not conjecture[1] -- what is misinformation is the assertion "...has been categorically shown to be untrue". Citation? I find that when people use "categorically" in an assertion (denial), then there's good reason for doubt. 1. https://www.forbes.com/sites/roberthart/2021/08/25/vaccine-protection-wanes-within-six-months-of-second-covid-shot-study-warns-but-theyre-still-effective-against-delta/?sh=7098eb6e5a80 https://www.forbes.com/sites/roberthart/2021/08/25/vaccine-p...