3 ms·
[1] is an interesting lit review on what drug strategies have been tried where in the world. None of these papers seem to present strong clinical evidence that
by rsfern 5y ago
[1] is an interesting lit review on what drug strategies have been tried where in the world.
None of these papers seem to present strong clinical evidence that these drugs have actually been effective, vs some hidden covariate or something. A couple include interesting small-sample observational studies, but as I understand it those haven’t panned out in follow-on randomized controlled trials that have been done.
There are also a couple essentially viewpoint articles that are interesting. [2] is basically a pharmacokinetic calculation motivating further study, but no clinical data.
[4] is a hypothesis piece about hydroxychloroquine that draws on nine other studies. Haven’t been able to evaluate those because [4] is not open access, but this is one of the drugs that has not lived up to expectations in various RCTs that have been completed…
- criticaltinker 5y agoFair enough, here are some high quality RCTs that provide the strong clinical evidence you're looking for. [1] Ivermectin in combination with doxycycline for treating COVID-19 symptoms: a randomized trial https://pubmed.ncbi.nlm.nih.gov/33983065/ https://pubmed.ncbi.nlm.nih.gov/33983065/ [2] Fluvoxamine: A Review of Its Mechanism of Action and Its Role in COVID-19 https://www.frontiersin.org/articles/10.3389/fphar.2021.652688/full https://www.frontiersin.org/articles/10.3389/fphar.2021.6526... [3] Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 https://pubmed.ncbi.nlm.nih.gov/33306283/ https://pubmed.ncbi.nlm.nih.gov/33306283/ [4] Remdesivir for the Treatment of Covid-19 - Final Report https://pubmed.ncbi.nlm.nih.gov/32445440/ https://pubmed.ncbi.nlm.nih.gov/32445440/