There's no problem having several wireguard connections enabled at the same time. Routes are selected per metrics/distance. E.g: A private virtual network bet

There's no problem having several wireguard connections enabled at the same time. Routes are selected per metrics/distance. E.g: A private virtual network between you and remote hosts won't be interrupted by the presence of a VPN service. The entry connection to the private network would be routed through the VPN service, though.