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mRNA vaccines deliver mRNA to the target cell, via merging a lipid bubble into the cell membrane and dumping the contents into the cytoplasm. The mRNA is then
by grey413 5y ago
mRNA vaccines deliver mRNA to the target cell, via merging a lipid bubble into the cell membrane and dumping the contents into the cytoplasm. The mRNA is then translated into a specially designed variant of the spike protein that is embedded facing out of the cell membrane. As it happens, the physical details of embedded protein translation means that the spike proteins never see the cytoplasm at all, being restricted to the endoplasmic reticulum.
- dfawcus 5y agoThanks. That is what I read, just that I couldn't remember the term "endoplasmic reticulum", and so used "cytoplasm" as a hand wavy stand in. :-)