3 ms·
key points: * glycans are a common carbohydrate found on cell surfaces that are known to modify lipids and proteins in a process called glycosylation. * previ
by panabee 5y ago
key points:
* glycans are a common carbohydrate found on cell surfaces that are known to modify lipids and proteins in a process called glycosylation.
* previously, it was assumed glycans only bind to lipids and proteins. the research team discovered glycans can also bind to RNA, discovering a new class of biomolecule called glycoRNA.
* subsequent experiments revealed this biomolecule is found in many different cell types, including animal, plant and microbial cells.
* glycans and RNA are traditionally distinct fields, but the lead author, ryan flynn, leveraged his RNA background to explore a question that glycan experts had considered unlikely to bear fruit.
* the immune system of people suffering from lupus, an autoimmune disease, targets several of the RNAs comprising glycoRNA. this suggests glycoRNA merits further research, as it may represent a link in pathogenesis and could offer scientists new therapeutic avenues if so.