So far a multitude of randomized clinical trials (RCTs) have tried but not found significant benefits from using Ivermectin to treat COVID-19 in a single-drug t

So far a multitude of randomized clinical trials (RCTs) have tried but not found significant benefits from using Ivermectin to treat COVID-19 in a single-drug treatment regime. However it's worth noting that certain multi-drug treatment regimes are looking quite promising [1][2]. Furthermore, early multi-drug treatment (before severe symptoms) using existing widely available medicines has been proven effective at reducing hospitalization and death [3][4][5][6][7]. Many front-line doctors have been using such techniques since the beginning of the pandemic, because they had to - as there were no vaccines yet and no RCTs to guide them so naturally the only option was using and combining existing medicines with established safety and efficacy profiles, the same strategy used for other difficult to treat diseases and cancers. [1] Ivermectin in combination with doxycycline for treating COVID-19 symptoms: a randomized trial https://pubmed.ncbi.nlm.nih.gov/33983065/ https://pubmed.ncbi.nlm.nih.gov/33983065/ [2] Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 https://pubmed.ncbi.nlm.nih.gov/33306283/ https://pubmed.ncbi.nlm.nih.gov/33306283/ [3] Timing of Antiviral Treatment Initiation is Critical to Reduce SARS-CoV-2 Viral Load https://ascpt.onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12543 https://ascpt.onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.1... [4] Clinical outcomes after early ambulatory multidrug therapy for high-risk SARS-CoV-2 (COVID-19) infection https://rcm.imrpress.com/EN/article/downloadArticleFile.do?attachType=PDF&id=5074 https://rcm.imrpress.com/EN/article/downloadArticleFile.do?a... [5] Early multidrug treatment of SARS-CoV-2 infection (COVID-19) and reduced mortality among nursing home (or outpatient/ambulatory) residents https://www.sciencedirect.com/science/article/abs/pii/S0306987721001419 https://www.sciencedirect.com/science/article/abs/pii/S03069... [6] Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19) https://scholarlycommons.henryford.com/cgi/viewcontent.cgi?article=1139&context=infectiousdiseases_articles https://scholarlycommons.henryford.com/cgi/viewcontent.cgi?a... [7] Multidrug treatment for COVID-19 https://www.jstage.jst.go.jp/article/ddt/advpub/0/advpub_2021.01005/_pdf https://www.jstage.jst.go.jp/article/ddt/advpub/0/advpub_202...