3 ms·
> COVID-19, on the other hand, has an overall 1.66% chance of killing someone (38,043,754 cases, 629,644 deaths) What you calculated is the case fatality rate
by criticaltinker 5y ago
> COVID-19, on the other hand, has an overall 1.66% chance of killing someone (38,043,754 cases, 629,644 deaths)
What you calculated is the case fatality rate (CFR), but the infection fatality rate (IFR) is a better representation of risk from SARS-COV-2 infection.
The global average IFR is recently estimated to be ~0.15% [1], which is extremely skewed by age.
All estimates of age stratified IFR show a gradient that decreases by orders of magnitude with age - we're talking IFRs below 0.003% for healthy young adults and children [2][3].
Furthermore, there is substantial evidence that the CFRs & IFRs are significant overestimates [5]. This completely changes the risk-reward tradeoff for many people.
I am not advocating against vaccination (it is a powerful tool that saves lives) - just spreading knowledge and illustrating the fact that everyone has a different risk-reward profile based on their age and health, and should make personal health decisions accordingly.
[1] Reconciling estimates of global spread and infection fatality rates of COVID- 19: An overview of systematic evaluations
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/eci.13554 https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/eci.13...
[2] Infection fatality rate of COVID-19 inferred from seroprevalence data
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947934/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947934/
[3] COVID-19 antibody seroprevalence in Santa Clara County, California
https://academic.oup.com/ije/article/50/2/410/6146069 https://academic.oup.com/ije/article/50/2/410/6146069
[4] Model-informed COVID-19 vaccine prioritization strategies by age and serostatus
https://science.sciencemag.org/content/sci/371/6532/916.full.pdf https://science.sciencemag.org/content/sci/371/6532/916.full...
[5] Evaluating the massive underreporting and undertesting of COVID-19 cases in multiple global epicenters
https://www.sciencedirect.com/science/article/pii/S253104372030129X https://www.sciencedirect.com/science/article/pii/S253104372...
- strenholme 5y agoI addressed the gist of your concerns elsewhere in the thread. There have been 2,630 deaths from COVID-19 for 18-29 year olds (never mind the suffering COVID-19 causes people in this age range) in the US. Something that causes 2,630 deaths is more risky than something causing 229 non-fatal hospital visits (the heart condition which has gotten far too much attention). In terms of IFR vs. case fatality rate, the most comprehensive metastudy you cite, https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/eci.13554 https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/eci.13... estimates that we only have 1 case per 10 infections (the Lau 2021 paper which claims we only have 1 case per 50-100 infections is obviously not true in the United States, since the cumulative COVID-19 case count is over 10% of the US population; don’t put too much faith in and do not cherry pick an individual study). Assuming an IFR 10x the CFR, we have a 0.16% IFR rate, which is still orders of magnitude larger than the 0.002% rate we are seeing with people who get that non-fatal heart condition after getting the vaccine (and there’s evidence that they are more likely to get the heart condition from an actual COVID-19 infection than from a vaccine)[1]. Before you repeat the “but young people” argument, an order of magnitude more young people have died from COVID-19 than have gotten that generally non-fatal Myocarditis heart condition after being vaccinated. So we know the risk factor of getting a vaccine is lower. [2] Critical thinking is one thing, but there are a lot of bad faith actors in the “COVID skepticism” movement. Roughly speaking, vaccines have a near-zero chance of having averse side effects, a significant chance of reducing spread of COVID-19 (I myself am still skeptical about the studies which claim vaccinated people still spread the virus to unvaccinated people, since we’re generally seeing an exponential decrease in COVID-19 cases in places where a higher percentage of people are vaccinated), and greatly reduce hospitalizations of people who get COVID-19 [3]. It’s well known that, in the US, skepticism of vaccines and public health measures, unfortunately, have a political bias, and, lo and behold, people with a “COVID denial” (deny that masks help [4], refuse to take the vaccine, refuse to avoid large indoor social gatherings, etc.) political bent are much more likely to get a case of COVID-19 significant enough to report: https://i.redd.it/4o4i7arucpj71.png https://i.redd.it/4o4i7arucpj71.png A lot of this “skepticism” I am seeing reminds me of the young earth creationist arguments which I have seen over the years; they will take any evidence for a young earth, no matter how tenuous, and pretend it’s the one truth while ignoring all of the extensive evidence for an old earth. It’s bad faith arguing; young earth creationists and anti-vaxx “skeptics” do not argue in good faith. This bad-faith skepticism -- which usually consists of poorly researched nonsense like claiming Myocarditis is a real concern if someone gets the vaccine -- is putting people in hospitals and bad-faith skepticism is killing people. I am having to avoid certain family members because they have drunk the kool-aid and refuse to vaccinate. [1] https://www.medrxiv.org/content/10.1101/2021.07.23.21260998v1 https://www.medrxiv.org/content/10.1101/2021.07.23.21260998v... [2] To address the “Rambo” argument that young people who do not have co-morbid conditions are unlikely to die from COVID-19, their chance of getting any adverse side effects from the vaccine is also very very low. See https://health.wusf.usf.edu/health-news-florida/2021-06-18/pfizers-covid-vaccine-in-teens-and-myocarditis-what-you-need-to-know https://health.wusf.usf.edu/health-news-florida/2021-06-18/p... [3] https://datawrapper.dwcdn.net/5Qts7/9/ https://datawrapper.dwcdn.net/5Qts7/9/ [4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393808/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393808/ shows that masks do help