3 ms·
> The new evidence shows that protective antibodies generated in response to an mRNA vaccine will target a broader range of SARS-CoV-2 variants carrying “single
by fouric 5y ago
> The new evidence shows that protective antibodies generated in response to an mRNA vaccine will target a broader range of SARS-CoV-2 variants carrying “single letter” changes in a key portion of their spike protein compared to antibodies acquired from an infection.
This seems like a remarkably specific criteria. Using my naive, computer-science brain, I would think that it's unlikely that a mutation would consist of exactly one change to the RBD amino acid sequence (compared to all of the other possible mutations). What am I missing?
- cblconfederate 5y agoA variant has multiple mutations which they call "single letter changes". It's not meant to say that there will be only one mutation per variant
- rolph 5y agosingle letter change is refered to as a point mutation meaning one residue. it is common there are a number of mutation types and numerous mechanisms. https://en.wikipedia.org/wiki/Mutation https://en.wikipedia.org/wiki/Mutation in the case of point mutations, cosmic ray ablation, and wobbly fit of the replication mechanism lead to data corruption, conflated by error prone replication or error prone proof reading