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this is referred to as a polyvalent vaccine, and it is a good thing to do once we understand enough about the antigens in question to incorporate both in one sh
by rolph 5y ago
this is referred to as a polyvalent vaccine, and it is a good thing to do once we understand enough about the antigens in question to incorporate both in one shot. There is nothing of course precluding two different vaccines of differenct valence, and we have been doing this for a short time now, when we combine single jab mRna vaccines, with adenoviral vectored vaccines, there is very slight sequence variation between adV and mRNA vaccines however by strictest interpretation this is a multivalant[bivalant] scenario.
- cblconfederate 5y agoit also generates immunity to the adenoviral vector proteins
- rolph 5y agoyes and this has been the big setback for many years this is why we dont have a lot of these vector vaccines. if someone is immune to adenovirus they typically destroy the vaccine before antigen can be presented. this reduces prophylactic opportunities regarding serial innoculation with adenovirus vector, regardless of the cassette load i am one of those people, having worked with adenovirus, as well as coronavirus, thus i am obligated to non adenoviral vaccine, and made out quite well during my infection with SARS-1, and with SARS-2
- cblconfederate 5y agoyou got infected with SARS1?
- rolph 5y agoyes i did, when it was brand new, it was very concerning, i was very congested, labouring to breath and walking was starting to feel like running a marathon in 90 degree weather. when SARS-2 came around it was a case of the sniffles, with very high antibody titre, searching on a whim i discovered that i am not alone, and apparently SARS-1 convalesence related to outcome of SARS-2 infection