Not directly in reply to your question, but an anecdote I thought might be relevant: I was recently reading more about Ignàc Semmelweis, the doctor famous for

Not directly in reply to your question, but an anecdote I thought might be relevant: I was recently reading more about Ignàc Semmelweis, the doctor famous for promoting hand washing. He was finding that hand washing had almost no impact on the outcomes in a particular hospital. He eventually discovered that they needed to wash the sheets better too. Either intervention alone would have almost no impact, but together they were powerful. Source: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(04)16022-4/fulltext https://www.thelancet.com/journals/lancet/article/PIIS0140-6...