4 ms·
Someone will have tons of antibodies 4-6 weeks later and then experience a drop off. Especially if you’re measuring from the first vaccine dose. This is litera
by robbiep 5y ago
Someone will have tons of antibodies 4-6 weeks later and then experience a drop off. Especially if you’re measuring from the first vaccine dose.
This is literally how the Adaptive immune system works.
Initial adaptive response, production of IgM, Vdj recombination, class switching and global proliferation (especially in the face of a repeated antigen insult), followed by a tone down of B cells as the memory effect is preserved and the antibody titre falls back (antibodies have a half life of 3-4 weeks).
Because (at least currently) the antibody response in humans is non-sterilising (talk of boosters to generate IgA abound, along with a more specific Delta variant vaccine may change this) you can’t equate a titre in humans yet with a ‘level’ of immunity
- rolph 5y agoyou as well understand at a deeper level