4 ms·
Thank you for the other references. > Down voted because this is misinformation I would hope you might agree that term is better reserved for bullshit conspir
by Treblemaker 5y ago
Thank you for the other references.
> Down voted because this is misinformation
I would hope you might agree that term is better reserved for bullshit conspiracy theories and not peer reviewed research published in one of the most cited journals in the world.
> the citation you provided does not support your claim
Upon re-reading the paper I still find that my claim is supported.
"Although antiviral T and B cell memory certainly contribute some degree of protection, strong evidence of a protective role for neutralizing serum antibodies exists. For example, passive transfer of neutralizing antibodies can prevent severe SARS-CoV-2 infection in multiple animal models,12,13 and Regeneron has recently reported similar data in humans14. We therefore focus our studies on in vitro virus neutralization titers reported in studies of vaccinated and convalescent cohorts"
"To compare neutralization titers across studies, we determined the mean and standard deviation (on a log scale) of the neutralization titer in published data from seven vaccine studies (mRNA-1273, NVX-CoV2373, BNT162b2, rAd26-S+rAd5-S, ChAdOx1 nCoV-19, Ad26.COV2.S and CoronaVac) and one convalescent study3,16,17,18,19,20,21,22"
" This model assumes that there is a protective neutralization level, T, above which individuals will be protected from infection and below which individuals will be susceptible. The protective efficacies observed in phase 3 clinical trials of vaccinated individuals (and another large cohort study of convalescent individuals1; "
[data shows higher level of neutralizing antibodies from four of the vaccines compared with convalescent studies]
It is possible -- even likely -- that I have misunderstood the paper. And both you and the paper I cited agree that more research is needed to establish the correlation between levels of neutralizing antibodies and protection from infection and disease. But my claim was _about_ the levels of neutralizing antibodies and as I understand it that claim is supported by the paper.