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PEI (German Institute for Vaccines) on 16 Mar 2021 (!) [1]: "(4) The number of these cases after vaccination with COVID-19 AstraZeneca is statistically signifi

PEI (German Institute for Vaccines) on 16 Mar 2021 (!) [1]: "(4) The number of these cases after vaccination with COVID-19 AstraZeneca is statistically significantly higher than the number of cerebral venous thromboses that normally occur in the unvaccinated population. For this purpose, an observed-versus-expected analysis was performed, comparing the number of cases expected without vaccination in a 14-day time window with the number of cases reported after approximately 1.6 million AstraZeneca vaccinations in Germany. About one case would have been expected, and seven cases had been reported." UK vaccine safety report up to 11 Aug 2021 [2]: "The overall incidence after first or unknown doses was 14.9 per million doses." German safety report up to 31 Jul 2021 [3, in German], cf. table 7,8: Women: 1.462 cases per 100k doses Men: 1.305 cases per 100k doses Can't find the numbers for Norway, they initially reported the highest number per 100k. > I'm not sure how likely it is. Do I understand correctly that there is no mechanism specific to how the mRNA vaccines work? The effect you describe ("we are exposing a spike protein on a cell wall") is far more common in Covid due to how the abundance of expression of the spike protein, correct? [1] https://www.pei.de/SharedDocs/Downloads/EN/newsroom-en/hp-news/faq-temporary-suspension-astrazeneca.pdf?__blob=publicationFile&v=7 https://www.pei.de/SharedDocs/Downloads/EN/newsroom-en/hp-ne... [2] https://www.gov.uk/government/publications/coronavirus-covid-19-vaccine-adverse-reactions/coronavirus-vaccine-summary-of-yellow-card-reporting https://www.gov.uk/government/publications/coronavirus-covid... [3] https://www.pei.de/SharedDocs/Downloads/DE/newsroom/dossiers/sicherheitsberichte/sicherheitsbericht-27-12-bis-31-07-21.pdf?__blob=publicationFile&v=5 https://www.pei.de/SharedDocs/Downloads/DE/newsroom/dossiers...

giantg2 5y ago
That's interesting. It looks like there is a lot of conflicting information on the background rate. And even the UK rate in the quote is higher than the Germany's, yet the article I linked to from the wiki is saying Germany's is higher, and that the estimates on background level vary wildly. Although if it is multiple times the normal rate, then this would not be an example of sensitive reporting/detection anyways (not to mention that EU reporting takes place outside of the VAERS system). "Do I understand correctly that there is no mechanism specific to how the mRNA vaccines work?" No. Covid does not add a spike protein to an existing cell. It replicates an entire covid cell. So you have covid virus with a spike and a bunch of other covid proteins if you have covid. Or you have a human cell with a partial spike and all the normal human cell proteins. The immune system usually codes off of, or attacks, multiple proteins. It's possible the immune system will identify the spike and some of the normal cell proteins. A similar sort of mimicry is theorized to occur when the proteins in a virus are similar enough to a human protein. https://www.nytimes.com/1996/12/31/science/virus-s-similarity-to-body-s-proteins-may-explain-autoimmune-diseases.html https://www.nytimes.com/1996/12/31/science/virus-s-similarit...

giantg2 5y ago

That's interesting. It looks like there is a lot of conflicting information on the background rate. And even the UK rate in the quote is higher than the Germany's, yet the article I linked to from the wiki is saying Germany's is higher, and that the estimates on background level vary wildly. Although if it is multiple times the normal rate, then this would not be an example of sensitive reporting/detection anyways (not to mention that EU reporting takes place outside of the VAERS system). "Do I understand correctly that there is no mechanism specific to how the mRNA vaccines work?" No. Covid does not add a spike protein to an existing cell. It replicates an entire covid cell. So you have covid virus with a spike and a bunch of other covid proteins if you have covid. Or you have a human cell with a partial spike and all the normal human cell proteins. The immune system usually codes off of, or attacks, multiple proteins. It's possible the immune system will identify the spike and some of the normal cell proteins. A similar sort of mimicry is theorized to occur when the proteins in a virus are similar enough to a human protein. https://www.nytimes.com/1996/12/31/science/virus-s-similarity-to-body-s-proteins-may-explain-autoimmune-diseases.html https://www.nytimes.com/1996/12/31/science/virus-s-similarit...