Naively, a small protein of ~100 amino acid residues has ~21^100 configurations. Amino acids average 110 Daltons each (110g/mol), you would need approximately

Naively, a small protein of ~100 amino acid residues has ~21^100 configurations. Amino acids average 110 Daltons each (110g/mol), you would need approximately 3*10^107kg of matter to build them all. There is an estimated 10^53kg of matter in the known universe.