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I think you’re seriously underestimating the scale of the genome and the number of possible combinations that might be responsible for some phenotype, even assu

I think you’re seriously underestimating the scale of the genome and the number of possible combinations that might be responsible for some phenotype, even assuming the genotype -> phenotype causality was straightforward (which it’s not). This is simply not a problem we’re going to computer our way through, at least until we have large scale quantum computers and way better data than we have today.

jcims 5y ago
Naively, a small protein of ~100 amino acid residues has ~21^100 configurations. Amino acids average 110 Daltons each (110g/mol), you would need approximately 3*10^107kg of matter to build them all. There is an estimated 10^53kg of matter in the known universe.