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Children and pregnant women are the two sub-populations I mentioned previously. > Given that COVID-19 disease is far milder in the majority of children than in

Children and pregnant women are the two sub-populations I mentioned previously. > Given that COVID-19 disease is far milder in the majority of children than in adults, the risk–benefit of a pediatric SARS-CoV-2 vaccine must be carefully weighed [0] > The prognostic significance, long-term implications and mechanism of this myocardial injury needs to be studied further, especially as vaccination efforts are rolled out to younger children. [1] > While the safety, immunogenicity, and efficacy data for the 4 authorized vaccines are reassuring so far, none of these vaccines has been systematically studied in pregnant and breastfeeding people [2] > it is important to remain transparent about the lack of information, acknowledge concerns, and support those who decide to defer vaccination until more data are available [2] [0] SARS-CoV-2 vaccine testing and trials in the pediatric population: biologic, ethical, research, and implementation challenges (Feb 2021) https://www.nature.com/articles/s41390-021-01402-z https://www.nature.com/articles/s41390-021-01402-z [1] COVID-19 Vaccination-Associated Myocarditis in Adolescents (August 2021) https://pediatrics.aappublications.org/content/pediatrics/early/2021/08/12/peds.2021-053427.full.pdf https://pediatrics.aappublications.org/content/pediatrics/ea... [2] SARS-CoV-2 Vaccination During Pregnancy: A Complex Decision (April 2021) https://academic.oup.com/ofid/article/8/5/ofab180/6220034 https://academic.oup.com/ofid/article/8/5/ofab180/6220034

handoflixue 5y ago
"Even so, given the reassuring safety and efficacy profiles of the SARS-CoV-2 vaccines that have gained UK/US regulatory authorization to date, the known risks of COVID-19 likely outweigh the unclear risks of SARS-CoV-2 vaccines for pregnant and breastfeeding people." What are you advocating for? Your own Source Two backs me up here - we have plenty of reason to conclude that Covid is the bigger risk despite the lack of studies. It's right there in the "Conclusion" section.
- criticaltinker 5y ago
  > the known risks of COVID-19 likely outweigh the unclear risks of SARS-CoV-2 vaccines for pregnant and breastfeeding people Emphasis on "likely" - the authors do not conclude with any certainty, they're speculating based on the available evidence, just like you. I guess your personal threshold for "plenty of reason to conclude" is lower than mine, and that's okay - to each their own. But it's very clearly spelled out in the sources I cited: currently there is limited evidence demonstrating the safety and benefit profiles needed to conclude that every child and every pregnant woman should be vaccinated.
  - handoflixue 5y ago
    Yeah, but in the absence of better information, we make do with what we have, and pregnant people get vaccinated, right? I see your point that more research is better, but given the current uncertainty you still have to decide whether Covid or Vaccine is the bigger risk, and all the science says that Covid is the bigger risk. I'm honestly not sure where we disagree.

handoflixue 5y ago

"Even so, given the reassuring safety and efficacy profiles of the SARS-CoV-2 vaccines that have gained UK/US regulatory authorization to date, the known risks of COVID-19 likely outweigh the unclear risks of SARS-CoV-2 vaccines for pregnant and breastfeeding people." What are you advocating for? Your own Source Two backs me up here - we have plenty of reason to conclude that Covid is the bigger risk despite the lack of studies. It's right there in the "Conclusion" section.

criticaltinker 5y ago
> the known risks of COVID-19 likely outweigh the unclear risks of SARS-CoV-2 vaccines for pregnant and breastfeeding people Emphasis on "likely" - the authors do not conclude with any certainty, they're speculating based on the available evidence, just like you. I guess your personal threshold for "plenty of reason to conclude" is lower than mine, and that's okay - to each their own. But it's very clearly spelled out in the sources I cited: currently there is limited evidence demonstrating the safety and benefit profiles needed to conclude that every child and every pregnant woman should be vaccinated.
- handoflixue 5y ago
  Yeah, but in the absence of better information, we make do with what we have, and pregnant people get vaccinated, right? I see your point that more research is better, but given the current uncertainty you still have to decide whether Covid or Vaccine is the bigger risk, and all the science says that Covid is the bigger risk. I'm honestly not sure where we disagree.