3 ms·Ketoconazole blocks hormone steroid synthesis and reduces testosterone levels.by plexman 5y agoKetoconazole blocks hormone steroid synthesis and reduces testosterone levels.morsch 5y agoWhen used externally?plexman 5y ago"Ketoconazole is not absorbed systemically after topical administration..." [1] It does not mean that it's not absorbed. [1] https://pubmed.ncbi.nlm.nih.gov/3280211/ https://pubmed.ncbi.nlm.nih.gov/3280211/