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It is my understanding that simply waiting for a longer time would not have helped. This side effect did not come much later after the vaccination, but only in

It is my understanding that simply waiting for a longer time would not have helped. This side effect did not come much later after the vaccination, but only in very rare cases, which is why it took some time to notice it. Considering how many people we vaccinated with the Covid vaccines, we should have seen (and have seen, with myocarditis, trombosis) such rare side effects. Plus, it is likely that the disease itself would have a similar effect on patients, because it is an interaction of the immune system with the nervous system. The vaccine itself is cleared from the body within weeks, after all, so it's not like medicine that is taken over a long period of time and can build up. So what you need is not longer trials, but trials with more people. Which is what is done in so called phase 4 trials after approval.

cies 5y ago
Side-effects may develop only after a while: a good reason for longer trials.
- learc83 5y ago
  There has never been a vaccine that was recalled because of side effects that didn't show up until over a year later.
  - hall0ween 5y ago
    Citation? It's a bold claim, without any evidence to back it up. HN is different than the comments section of a news site.
    - learc83 5y ago
      Look through a list of vaccine safety recalls. Here's a highlight of the big ones--this is the list that most vaccine hesitant people talk about when they discuss their issues with vaccine safety. https://www.cdc.gov/vaccinesafety/concerns/concerns-history.html https://www.cdc.gov/vaccinesafety/concerns/concerns-history.... None of the side effects in that list took more than a few weeks to occur, and the majority them happened within a few days. >HN is different than the comments section of a news site. Tell me again how hacker news isn't reddit O user of 3 months.
      - hall0ween 5y ago
        Content for one, do you see many memes here? tik tok videos? pictures of dogs and cats? Typically the dialogue is more...dialogue than just cynicism. What's your reasoning it is Reddit?
      - hall0ween 5y ago
        Thanks for the list too. Looking at the examples from the 90s on - aside from the rotavirus vaccine - this looks like a list of examples for why there should not be concern. Concerns were raised for vaccines and subsequently found to be uncorrelated. Regardless of interpretation too, this doesn't support the claim the commenter made - there has never been a vaccine recalled within a year.
  - cies 5y ago
    There was never a major mRNA vaccine roll out ever. mRNA possibly does not compare to traditional vaccines, there's evidence it is a different beast entirely. Enough reason to be cautious, wait out the hidden/late-onset side effect, and not give it to those not too vulnerable to covid. But authorities claim it's totally safe for all ages, while they have no data to back this up (that'd need a long trial, and those taking it ARE the long trial).
    - learc83 5y ago
      Multiple mRNA vaccines have been tested on humans since 2008 and on animals before that. None of them produced any “late-onset” side effects. And there is no sound theoretical mechanism for late-onset mRNA side effects. No drug approval process works like what you are proposing. Hundreds of millions of people have had nearly a year to develop side effects—-the safety profile is very well known at this point.

cies 5y ago

Side-effects may develop only after a while: a good reason for longer trials.

learc83 5y ago
There has never been a vaccine that was recalled because of side effects that didn't show up until over a year later.
- hall0ween 5y ago
  Citation? It's a bold claim, without any evidence to back it up. HN is different than the comments section of a news site.
  - learc83 5y ago
    Look through a list of vaccine safety recalls. Here's a highlight of the big ones--this is the list that most vaccine hesitant people talk about when they discuss their issues with vaccine safety. https://www.cdc.gov/vaccinesafety/concerns/concerns-history.html https://www.cdc.gov/vaccinesafety/concerns/concerns-history.... None of the side effects in that list took more than a few weeks to occur, and the majority them happened within a few days. >HN is different than the comments section of a news site. Tell me again how hacker news isn't reddit O user of 3 months.
    - hall0ween 5y ago
      Content for one, do you see many memes here? tik tok videos? pictures of dogs and cats? Typically the dialogue is more...dialogue than just cynicism. What's your reasoning it is Reddit?
    - hall0ween 5y ago
      Thanks for the list too. Looking at the examples from the 90s on - aside from the rotavirus vaccine - this looks like a list of examples for why there should not be concern. Concerns were raised for vaccines and subsequently found to be uncorrelated. Regardless of interpretation too, this doesn't support the claim the commenter made - there has never been a vaccine recalled within a year.
- cies 5y ago
  There was never a major mRNA vaccine roll out ever. mRNA possibly does not compare to traditional vaccines, there's evidence it is a different beast entirely. Enough reason to be cautious, wait out the hidden/late-onset side effect, and not give it to those not too vulnerable to covid. But authorities claim it's totally safe for all ages, while they have no data to back this up (that'd need a long trial, and those taking it ARE the long trial).
  - learc83 5y ago
    Multiple mRNA vaccines have been tested on humans since 2008 and on animals before that. None of them produced any “late-onset” side effects. And there is no sound theoretical mechanism for late-onset mRNA side effects. No drug approval process works like what you are proposing. Hundreds of millions of people have had nearly a year to develop side effects—-the safety profile is very well known at this point.