3 ms·
> All were doing well clinically with resolution of their symptoms in most. Seven patients (13%) reported non-specific symptoms including intermittent atypica
by kafkaIncarnate 5y ago
> All were doing well
clinically with resolution of their symptoms in most. Seven patients (13%) reported non-specific
symptoms including intermittent atypical chest pain (4), palpitations (2) and mild fatigue with
minimal activity (1). All patients had normal ventricular function, based on echocardiography.
The 4 patients who had presented with arrhythmias earlier continue to be in normal sinus rhythm
with no recurrence.
> Follow up CMR studies have been scheduled and are
pending at the time of this submission for rest of the patients. There were no acute events, re-
hospitalization or deaths reported.
> Although myocarditis following immunizations against smallpox, influenza, and tetanus is well
recognized, 13-16 the experience in children with vaccine associated myocarditis, other than
following COVID-19 vaccination is limited. Importantly, myocarditis was not reported following the clinical trials of mRNA COVID-19 vaccines.17,18 This may be related to the limited number
of patients in the clinical trials and reflective of the apparent rarity of this complication.19
> The present study adds the following information to our understanding of myocarditis related to
the COVID-19 vaccine: 1. Myocarditis following mRNA vaccines is associated with acute myocardial injury and
edema of the myocardium, in the presence of preserved ventricular function. 2. The initial clinical course and short-term outcomes are good and reassuring. 3. There is no apparent difference in clinical characteristics and outcomes between 12–15-
year-olds and older adolescents. 4. The clinical picture is distinct from multisystem inflammatory syndrome in children (MIS-
C) and appears to be less severe.
> Limitations of our study include its retrospective nature, combining patients from 16 different
institutions which used similar, but not identical approaches during the work-up and management
of childhood myocarditis. Our cases represent a selected cohort which may not necessarily be
representative of the general pediatric population.
Also, preprint despite being through peer-review might change their conclusions based on the fact that the discussion section conflicts, low N values, etc.
Seems less of a problem than the blood-clots, though should be something doctors be aware of while vaccinating children to be certain it isn't happening. Looks like it's being treated successfully and heals appropriately, though, with existing medicine.