Agree with all of this. The maddening part for us has been that Snakemake, which like for the parent poster has been the best workflow management system for us

Agree with all of this. The maddening part for us has been that Snakemake, which like for the parent poster has been the best workflow management system for us, is not as widely supported across commercial platforms , and is somewhat less big PaaS enabled than e.g. nextflow. On the one hand Snakemake does support kubernetes, but on the other hand we are a bioinformatics research group and don’t have k8s engineers :/ (Scaling) Optimal workflow management for genome informatics groups is still very much an open problem.