3 ms·
This outlook ignores a critical factor. Intramuscular vaccine delivery did not confer high levels of mucosal immunity. However, subsequent infection of the va
by anonuser123456 5y ago
This outlook ignores a critical factor.
Intramuscular vaccine delivery did not confer high levels of mucosal immunity. However, subsequent infection of the vaccinated may provide excellent systemic protection while allowing mucosal immunity to naturally develop as a consequence of infection.
If high levels of mucosal immunity develop as a result of breakthrough infection, that may go a long way towards reducing r0.
Further, nasal delivery covid vaccines are underdevelopment. These may also provide mucosal immunity.
So there is still a very plausible way out of the pandemic that includes the near eradication of the disease.