To add to the other good comments, I think the best strategy is to find a really small organization with a laser focus, just a few million in run rate and less

To add to the other good comments, I think the best strategy is to find a really small organization with a laser focus, just a few million in run rate and less than a few dozen key staff. A small number of focused and passionate people can move mountains, just like in a startup. One you have vetted them, give them just enough to reach their next level of effectiveness, but with lots of strings and accountability. Think like a VC, is this team capable of getting the job done? Can their work be scaled with more capital? There are good giant charities, but you're too small a fish for them. The "membership" programs at most charities are just lead gen pipelines for major gifts and breaking even on marketing cost is pretty normal no matter what the little expenses pie charts say. If you are wealthy enough that the CEO of MSF is talking to you then you then disregard what I just said and consult your staff who runs your personal foundation.