4 ms·
i was wondering this the other day. the next big mutations may not be more infectious because they can survive outside the body longer, but because they get ar
by toiletaccount 5y ago
i was wondering this the other day.
the next big mutations may not be more infectious because they can survive outside the body longer, but because they get around existing immunity or theres a longer asympomatic-but-still-transmissible phase. theres a lot of different paths this could take to mass infection.
- tehjoker 5y agoReceptor binding affinity can also increase too, or like Alpha did, further suppress interferon production. Lots of ways...
- T-A 5y agoThat reminds me of this scary preprint from January: https://www.biorxiv.org/content/10.1101/2021.01.06.425392v3 https://www.biorxiv.org/content/10.1101/2021.01.06.425392v3 "in vitro evolution enhancing binding by 600-fold provides guidelines towards potentially new evolving mutations with even higher infectivity" :/
- tehjoker 5y agoI saw that yesterday and didn't post it because it was too scary lol