Mice/rats are a decent model, you just have to know how to extrapolate: - toxicity - rats are actually pretty good once you correct for metabolism (divide LD50

Mice/rats are a decent model, you just have to know how to extrapolate: - toxicity - rats are actually pretty good once you correct for metabolism (divide LD50 by 6). Humans and rats consume lots of xenobiotics due to our versatile diets - neuroscience, anything below the prefrontal cortex is pretty well conserved between rats and primates - cancer - kinda garbage. Mice and rats get cancer at the drop of a hat. But if it doesn't give rats cancer, that's a really good indicator of safety - exercise - generally extrapolates pretty well The worst is probably things like higher neuroscience, Alzheimers, and diet. Mice in particular are more vulnerable to high fat and high sugar diets than humans. It's fairly easy to induce diabetes in mice, but again, useful in that it increases sensitivity. But also means anti-diabetes drugs may have exaggerated effects.