It's more than that; sugar spiking your insulin regularly in an unnatural way (things way more sweet than our DNA is "trained" on, effects on gut microbiome, as

It's more than that; sugar spiking your insulin regularly in an unnatural way (things way more sweet than our DNA is "trained" on, effects on gut microbiome, association with ultra-processed foods devoid of fiber, healthy fats and quality protein, effects on appetite, neurological / addictive effects. And so on. All intrinsic negatives of sugar in the diet, it's not about the calories as this excerpt seems to imply.