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OK, I'll bite. If the vaccines are as effective as the numbers in the article suggest, why is Israel suggesting booster shots? The lowest suggested efficiency r

by jdhn 5y ago

OK, I'll bite. If the vaccines are as effective as the numbers in the article suggest, why is Israel suggesting booster shots? The lowest suggested efficiency rate is 81% for those in the 80-89 age category, this seems pretty good, no?

TheCoelacanth 5y ago
Efficacy is currently high, but that doesn't mean it still will be in 12 months without booster shots.
- jdhn 5y ago
  In regards to that, it hasn't been 12 months since the first round of shots. Does this mean that vaccinated people will have to get boosters every 4 - 6 months due to dropping efficacy?
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  - __blockcipher__ 5y ago
    They almost certainly will, yes. Especially given that all the popular vaccines are spike protein vaccines only, which are relatively easy for SARS-2 to “learn” how to evade. Exposure to the whole virus provides a much broader set of epitopes for the immune system to learn. I’d add that anyone who got vaccinated so that they can show proof of vaccination needs to understand that there’s no getting off the train. If you don’t get your booster you’ll be - gasp! - not fully vaccinated.
    - somewhereoutth 5y ago
      Exposure to the whole virus also produces a bunch of immune disregulating components which help make this virus particularly nasty. People get vaccinated to protect themselves and others around them - boosters will increase that protection. Proof of vaccination is about excluding those who haven't been vaccinated - it is they who are on the train, though they can get off it anytime they choose.
  - anonuser123456 5y ago
    Maybe, maybe not. Current vaccines do not target mucosal immunity, but intranasal and inhaler delivery are being worked on in other vaccines. Mucosal immunity would help reduce R0 and drive the disease to manageable levels.
  - perl4ever 5y ago
    Recently I saw it stated that people may need one in about 8 months. For the general population, I don't think that's going to be much before January.
simplyaccont 5y ago
because hospitals filling too quickly and there is only so much beds.
s1artibartfast 5y ago
really depends on what the baseline is.

by jdhn 5y ago

TheCoelacanth 5y ago

Efficacy is currently high, but that doesn't mean it still will be in 12 months without booster shots.

jdhn 5y ago
In regards to that, it hasn't been 12 months since the first round of shots. Does this mean that vaccinated people will have to get boosters every 4 - 6 months due to dropping efficacy?
- deleted 5y ago
  [deleted]
- deleted 5y ago
  [deleted]
- __blockcipher__ 5y ago
  They almost certainly will, yes. Especially given that all the popular vaccines are spike protein vaccines only, which are relatively easy for SARS-2 to “learn” how to evade. Exposure to the whole virus provides a much broader set of epitopes for the immune system to learn. I’d add that anyone who got vaccinated so that they can show proof of vaccination needs to understand that there’s no getting off the train. If you don’t get your booster you’ll be - gasp! - not fully vaccinated.
  - somewhereoutth 5y ago
    Exposure to the whole virus also produces a bunch of immune disregulating components which help make this virus particularly nasty. People get vaccinated to protect themselves and others around them - boosters will increase that protection. Proof of vaccination is about excluding those who haven't been vaccinated - it is they who are on the train, though they can get off it anytime they choose.
- anonuser123456 5y ago
  Maybe, maybe not. Current vaccines do not target mucosal immunity, but intranasal and inhaler delivery are being worked on in other vaccines. Mucosal immunity would help reduce R0 and drive the disease to manageable levels.
- perl4ever 5y ago
  Recently I saw it stated that people may need one in about 8 months. For the general population, I don't think that's going to be much before January.

simplyaccont 5y ago

because hospitals filling too quickly and there is only so much beds.

s1artibartfast 5y ago

really depends on what the baseline is.