> It's wonderfully surprising that body can have bunch of free floating DNA constructs inside without triggering strong immune response. I would be very scared

> It's wonderfully surprising that body can have bunch of free floating DNA constructs inside without triggering strong immune response. I would be very scared of a free floating DNA machinery therapeutic, as Lupus is associated with anti-dsDNA, (to be fair we don't know what direction the causal arrow is), and it's such a long and chronic condition that I would doubt the ability to model it in early stage preclinical or even find it in phase I safety. For some conditions phase 4 is way too late.