3 ms·
Patrick Collison, one of the funders of this research via the Fast Grants program (https://fastgrants.org/ https://fastgrants.org/), tweeted an excellent summar
by worldvoyageur 5y ago
Patrick Collison, one of the funders of this research via the Fast Grants program (https://fastgrants.org/ https://fastgrants.org/), tweeted an excellent summary the results a few days ago:
https://twitter.com/patrickc/status/1427367934880469010 https://twitter.com/patrickc/status/1427367934880469010
n=1,472 patients;
~1/3 reduction in hospitalization;
now pursuing a larger scale trial to replicate the results
The actual research results are here:
https://www.frontiersin.org/articles/10.3389/fphar.2021.652688/full https://www.frontiersin.org/articles/10.3389/fphar.2021.6526...
From the paper, dosage in the trial was:
"
Participants received 50 mg FLV QD on day 1, then for 2 days 100 mg FLV BID, and then 100 mg FLV TID as tolerated through day 15 and then stopped.
"
Fluvoxamine has been long off patent. Based on my slap-dash googling of online pharmacies, this treatment would cost under US$10 total.
The hypothesized mechanisms of action are the anti-inflammatory, anti-platelet, and potentially antiviral activities which are side effects of Fluvoxamine's psychoactive properties. These mechanisms would counter some of the more serious body responses to the more severe cases of covid.
- chriscappuccio 5y agoAll sigma 1 agonists in test for covid seem to work very well to prevent serious disease symptoms and death. They appear to modulate the immune system's response to the virus (including cytokine storm) which is what causes most of the damage.