And really, even if you know python or R, are you really going to fire up a jupyter notebook, load the data, and run pandas queries every time someone in lab me

And really, even if you know python or R, are you really going to fire up a jupyter notebook, load the data, and run pandas queries every time someone in lab meeting or after a talk asks you about this gene or that gene in your data? I don't do any scientific research, but I have been using jupyter as a replacement for excel since it was called the ipython notebook. I don't really use pandas all that often, I just find it easier to read and edit data in python. Though I first learned ipython added the notebook from a talk Wes McKinney gave about Pandas.