4 ms·

How long does covid immunity after natural infection last?

dsincl12 5y ago
Probably for life and that includes variants as well. See https://www.cell.com/cell/fulltext/S0092-8674(20)31008-4 https://www.cell.com/cell/fulltext/S0092-8674(20)31008-4
rolph 5y ago
there is evidence that Tcell based immunity remains for more than a decade [i.e 17 years] as evidenced by competent immune response of sars survivors when challenged by sars2 [covid19] the real concern should be the inverse of your question, ie how long does it take for the sars2 to generate variants that will escape a contemporary vaccine. there are other considerations such as the neutralizing antibody criterion . there is a sweet spot of prophylactic vaccination; a span of time exists post innocuum where neutralizing antibodies are at the greatest titre and the best chance of destroying a viral agent before infection can occur will exist. this is a good bullseye to aim for, however unreasonable to expect high degree of accuracy or timing regarding titre and pathogenic challenge. the thing with non-neutralizing antibodies are that they are lables flagging a foriegn antigen these are referred to as opsonising antibodies and lable antigens for phagocytosis by macrophages. roughly 6-8 months is the official endorsement regarding duration of naturally aquired immunity; this is probably somewhat longer in duration however the virus changes quickly; at this point one should expect roughly 12 monthes before "boosting" is absolutely required. I suspect arbitrarily that boosting will soon succumb to a reformulation in order to match vaccine closely to novel viral epitopes. this is the same sort of dynamic that "the cold" follows, thats why we always catch it often very mild sometimes very bad due to variation of previous challenger, and cesation of antibody production. [adndm] here is a short piece regarding the above: https://www.pennmedicine.org/news/news-releases/2021/august/penn-study-details-robust-tcell-response-to-mrna-covid19-vaccines https://www.pennmedicine.org/news/news-releases/2021/august/... https://www.cell.com/immunity/fulltext/S1074-7613(21)00308-3 https://www.cell.com/immunity/fulltext/S1074-7613(21)00308-3

Probably for life and that includes variants as well. See https://www.cell.com/cell/fulltext/S0092-8674(20)31008-4 https://www.cell.com/cell/fulltext/S0092-8674(20)31008-4

rolph 5y ago

there is evidence that Tcell based immunity remains for more than a decade [i.e 17 years] as evidenced by competent immune response of sars survivors when challenged by sars2 [covid19] the real concern should be the inverse of your question, ie how long does it take for the sars2 to generate variants that will escape a contemporary vaccine. there are other considerations such as the neutralizing antibody criterion . there is a sweet spot of prophylactic vaccination; a span of time exists post innocuum where neutralizing antibodies are at the greatest titre and the best chance of destroying a viral agent before infection can occur will exist. this is a good bullseye to aim for, however unreasonable to expect high degree of accuracy or timing regarding titre and pathogenic challenge. the thing with non-neutralizing antibodies are that they are lables flagging a foriegn antigen these are referred to as opsonising antibodies and lable antigens for phagocytosis by macrophages. roughly 6-8 months is the official endorsement regarding duration of naturally aquired immunity; this is probably somewhat longer in duration however the virus changes quickly; at this point one should expect roughly 12 monthes before "boosting" is absolutely required. I suspect arbitrarily that boosting will soon succumb to a reformulation in order to match vaccine closely to novel viral epitopes. this is the same sort of dynamic that "the cold" follows, thats why we always catch it often very mild sometimes very bad due to variation of previous challenger, and cesation of antibody production. [adndm] here is a short piece regarding the above: https://www.pennmedicine.org/news/news-releases/2021/august/penn-study-details-robust-tcell-response-to-mrna-covid19-vaccines https://www.pennmedicine.org/news/news-releases/2021/august/... https://www.cell.com/immunity/fulltext/S1074-7613(21)00308-3 https://www.cell.com/immunity/fulltext/S1074-7613(21)00308-3