4 ms·

At moment there is PrEP for that case. https://www.cdc.gov/hiv/basics/prep.html https://www.cdc.gov/hiv/basics/prep.html I think the idea in long term would,

At moment there is PrEP for that case. https://www.cdc.gov/hiv/basics/prep.html https://www.cdc.gov/hiv/basics/prep.html I think the idea in long term would, should be to replace PrEP.

Traubenfuchs 5y ago
I think marketingwise the vaccine will have a very, very hard time against PrEP, unless it can be proven that it's just as effective. And what about booster shots? It would be highly unethical to give someone an experimental vaccine INSTEAD of just PrEP. But if we don't do that, we can never find out how good the vaccine works. A dilemma.
- bluGill 5y ago
  > I think marketingwise the vaccine will have a very, very hard time against PrEP Probably not. PrEP has some nasty side effects. Those who take it need to get their organ function checked every few months (I think just kidneys?). Of course this vaccine is just entering trials. We have no idea how effective it is, or what the side effects might be. As such we can only guess and hope that it is better than PrEP - though that is a somewhat low bar.
  - vsef 5y ago
    To be clear, Truvada (or Descovy) for vast majority of people will have essentially no side effects. There is a small increase in chance of kidney disease, mainly for those with other risk factors, the risk profile is similar to over the counter ibuprofen. "HIV-positive individuals who use Truvada to control their infection are more likely to experience kidney damage and bone density loss than those who take it to prevent HIV infection, as so-called pre-exposure prophylaxis (PrEP)[2]. But “no significant health effects have been seen in people who are HIV-negative and have taken PrEP for up to 5 years,” according to the U.S. Department of Health and Human Services. Numerous studies have shown that the risk of HIV-negative Truvada users developing kidney disease is not statistically significantly different from those taking placebo[3]." https://healthfeedback.org/claimreview/hiv-drug-truvada-linked-to-kidney-damage-and-bone-density-loss-but-risks-are-low-and-usually-outweighed-by-the-drugs-benefits/ https://healthfeedback.org/claimreview/hiv-drug-truvada-link...
  - websites2023 5y ago
    > PrEP has some nasty side effects. Those who take it need to get their organ function checked every few months (I think just kidneys?). Please don’t spread this FUD. The side effects are rare and reversible by stopping the medicine. The checks are also required to check for other STIs.
    - bluGill 5y ago
      That doesn't mean they are not nasty or don't need be checked for. Better than HIV/AIDS for sure, but common enough that a vaccine could be better.
- hannob 5y ago
  Take a pill every day vs. get a vaccine every few years? I don't think the vaccine will have a marketing problem.
- _trampeltier 5y ago
  I think the first guys who tryed PrEP had to have also big balls to play with the fire. The price for PrEP is also very different from country to country. In some countrys it's almost for free, in some others is very, very expensive.
notorious-dto 5y ago
They will want you to take both the vaccine and PrEP, because (surprise!) the vaccine will not be 100% effective.
- Broken_Hippo 5y ago
  No vaccine is 100% effective. No medicine seems to be 100% effective either. This is a known issue, and it always has been. Good thing we don't need it to be to eradicate an illness. It won't be necessary for most folks to take both, though, that's just not how things work.
- barfingclouds 5y ago
  Let’s wait for the results before we decide what they mean

At moment there is PrEP for that case. https://www.cdc.gov/hiv/basics/prep.html https://www.cdc.gov/hiv/basics/prep.html I think the idea in long term would, should be to replace PrEP.

Traubenfuchs 5y ago

I think marketingwise the vaccine will have a very, very hard time against PrEP, unless it can be proven that it's just as effective. And what about booster shots? It would be highly unethical to give someone an experimental vaccine INSTEAD of just PrEP. But if we don't do that, we can never find out how good the vaccine works. A dilemma.

bluGill 5y ago
> I think marketingwise the vaccine will have a very, very hard time against PrEP Probably not. PrEP has some nasty side effects. Those who take it need to get their organ function checked every few months (I think just kidneys?). Of course this vaccine is just entering trials. We have no idea how effective it is, or what the side effects might be. As such we can only guess and hope that it is better than PrEP - though that is a somewhat low bar.
- vsef 5y ago
  To be clear, Truvada (or Descovy) for vast majority of people will have essentially no side effects. There is a small increase in chance of kidney disease, mainly for those with other risk factors, the risk profile is similar to over the counter ibuprofen. "HIV-positive individuals who use Truvada to control their infection are more likely to experience kidney damage and bone density loss than those who take it to prevent HIV infection, as so-called pre-exposure prophylaxis (PrEP)[2]. But “no significant health effects have been seen in people who are HIV-negative and have taken PrEP for up to 5 years,” according to the U.S. Department of Health and Human Services. Numerous studies have shown that the risk of HIV-negative Truvada users developing kidney disease is not statistically significantly different from those taking placebo[3]." https://healthfeedback.org/claimreview/hiv-drug-truvada-linked-to-kidney-damage-and-bone-density-loss-but-risks-are-low-and-usually-outweighed-by-the-drugs-benefits/ https://healthfeedback.org/claimreview/hiv-drug-truvada-link...
- websites2023 5y ago
  > PrEP has some nasty side effects. Those who take it need to get their organ function checked every few months (I think just kidneys?). Please don’t spread this FUD. The side effects are rare and reversible by stopping the medicine. The checks are also required to check for other STIs.
  - bluGill 5y ago
    That doesn't mean they are not nasty or don't need be checked for. Better than HIV/AIDS for sure, but common enough that a vaccine could be better.
hannob 5y ago
Take a pill every day vs. get a vaccine every few years? I don't think the vaccine will have a marketing problem.
_trampeltier 5y ago
I think the first guys who tryed PrEP had to have also big balls to play with the fire. The price for PrEP is also very different from country to country. In some countrys it's almost for free, in some others is very, very expensive.

notorious-dto 5y ago

They will want you to take both the vaccine and PrEP, because (surprise!) the vaccine will not be 100% effective.

Broken_Hippo 5y ago
No vaccine is 100% effective. No medicine seems to be 100% effective either. This is a known issue, and it always has been. Good thing we don't need it to be to eradicate an illness. It won't be necessary for most folks to take both, though, that's just not how things work.
barfingclouds 5y ago
Let’s wait for the results before we decide what they mean