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I don't think Aubrey de Grey is a good guy, and for anyone that is seriously interested in longevity research, it is known that he is mostly an old mascot that
by hobofan 5y ago
I don't think Aubrey de Grey is a good guy, and for anyone that is seriously interested in longevity research, it is known that he is mostly an old mascot that has kicked off a lot of (public, though not so much scientific) discourse in that field, but he and his foundation hasn't produced much by themselves.
Having said all that, the dismissal of longevity(/rejuvenation) research in general by the author (and many of the comments here) is incredibly shallow. While Aubrey de Grey highlights his mitochondiral research in his book "Ending Aging"[0], he never claims that it is a silver bullet for aging and most off the book revolves around different parts to the puzzle that have all to be solved in order for consistent rejuvenation to succeed.
A few years later "The Hallmarks of Aging"[1] (which outlines a similar approach to the book) was published in Cell and is widely recognized as a milestone paper and "roadmap" on what problems need to be tackled on the road to longevity. There are also now many biotech startups tackling exactly those problems outlined, producing real drugs that are currently in trials (e.g. Unity Biotechnology[2]), and the rate of more of them popping up is only accelerating.
I could try to write even more here to convince you that longevity research is a worthwile pursuit (and not just vaporware), but it's probably better if you read up on the topic for yourself, for which I can strongly recommend /r/longevity[3] and the resources listed there.
[0]: https://www.amazon.com/Ending-Aging-Rejuvenation-Breakthroughs-Lifetime/dp/0312367074 https://www.amazon.com/Ending-Aging-Rejuvenation-Breakthroug...
[1]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836174/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836174/
[2]: https://unitybiotechnology.com/pipeline/ https://unitybiotechnology.com/pipeline/
[3]: https://www.reddit.com/r/longevity/ https://www.reddit.com/r/longevity/
- xiphias2 5y agoOne more link that tries to collect current clinical trials: https://www.lifespan.io/road-maps/the-rejuvenation-roadmap/ https://www.lifespan.io/road-maps/the-rejuvenation-roadmap/ And an example for success for treating mitochondrial disease: https://www.lifespan.io/road-maps/the-rejuvenation-roadmap/gensight-biologics-gs010-lumevoq https://www.lifespan.io/road-maps/the-rejuvenation-roadmap/g... https://www.gensight-biologics.com/product/gs010-for-lhon/ https://www.gensight-biologics.com/product/gs010-for-lhon/ Sure, it's not moving mitochondrial DNA to Nucleus directly, but the vector allows a specific mitochondrial gene to be expressed inside the nucleus. In the future base / prime editing (which didn't exist 10 years ago) can be used to fix mitochondrial DNA damage, which is probably much better solution: https://www.nature.com/articles/d41586-020-02054-5 https://www.nature.com/articles/d41586-020-02054-5 So far the car maintainence metaphore of curing aging seems right.