I see. So the issue isn’t so much a neutralizing antibody mismatch, but rather an antibody production lag in b cells. That makes covid a long run big problem.

I see. So the issue isn’t so much a neutralizing antibody mismatch, but rather an antibody production lag in b cells. That makes covid a long run big problem. We’ll have to be repeatedly challenged with the antigen to keep antibody levels high. Kind of a minor inconvenience for some, but a large % of the population will not comply. Edit: It would seem that it is basically speculation at this point. Memory b-cell response effectiveness will depend on the binding affinity of its antibodies. A high binding affinity antibody producing memory cell will much more rapidly mount an effective response than one that must undergo further affinity maturation.