Here's a full text link [1]. This Letter To The Editor is an incremental contribution to the literature on SARS-CoV-2 antibody dependent enhancement. It does no

Here's a full text link [1]. This Letter To The Editor is an incremental contribution to the literature on SARS-CoV-2 antibody dependent enhancement. It does not attempt to quantify the health risks to individuals who have been vaccinated or naturally infected. > The aim of the present study was to evaluate the recognition of SARS-CoV-2 Delta variants by infection enhancing antibodies directed against the NTD. The antibody studied is 1054 (pdb file #7LAB) which has been isolated from a symptomatic Covid-19 patient. > Using molecular modelling approaches, we show that enhancing antibodies have a higher affinity for Delta variants than for Wuhan/D614G NTDs > in the case of the Delta variant, neutralizing antibodies have a decreased affinity for the spike protein, whereas facilitating antibodies display a strikingly increased affinity. > In conclusion, ADE may occur in people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors) and then exposed to a Delta variant. Although this potential risk has been cleverly anticipated before the massive use of Covid-19 vaccines, the ability of SARS-CoV-2 antibodies to mediate infection enhancement in vivo has never been formally demonstrated. [1] Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination? https://www.journalofinfection.com/article/S0163-4453(21)00392-3/fulltext https://www.journalofinfection.com/article/S0163-4453(21)003...