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Very cool and promising. Is there any literature on this "immune system in a dish", or is it ,understandably, proprietary? Three main Q: * How's reception bee

Very cool and promising. Is there any literature on this "immune system in a dish", or is it ,understandably, proprietary? Three main Q: * How's reception been with med chemists? * How do you expect cost to compare with some of the individual existing immunological wet lab screens? No individual numbers, just comparative would be interesting to know. * How granular is data collection for this kinda all-in-one system, and is throughput high enough to collect data and build predictive models alongside it? I used to work in the earlier stages of drug discovery and advances in these assays are fascinating. Really exciting work, guys!

rdifazio 5y ago
There are some reviews on immune organoids that I posted below. This is the first human one though able to recapitulate these features at a commercial scale. We haven't gotten any feedback from med chemists yet! The cost is comparable to other in vitro systems and is cheaper than using animals. *The data collection can be very granular. You can use single cell techniques like flow and RNA-seq to generate high resolution data. You can also use high resolution imaging techniques like CODEX. Moving into high throughput and building predictive models is exactly where we want to go. Currently, we can generate 7500 organoids from a single donor and screen them in the thousands. We're working on building a ML pipeline along with automation so that we can screen in the hundreds of thousands if not more. Key to this though is that we have designed a platform that is amenable to this kind of automation and scale.
- whymauri 5y ago
  Oh wow, your upcoming plans sound great. Keep up the good work guys! And I highly recommend reaching out to a med chemist for some input. There's a lot of veteran retirees specializing in spaces adjacent to this who are open to consulting here and there. They're generally quite kind.
  - rdifazio 5y ago
    Thank you! If you have a good recommendation, we'd love an introduction. Please let me know at robert at parallel.bio.

rdifazio 5y ago

There are some reviews on immune organoids that I posted below. This is the first human one though able to recapitulate these features at a commercial scale. We haven't gotten any feedback from med chemists yet! The cost is comparable to other in vitro systems and is cheaper than using animals. *The data collection can be very granular. You can use single cell techniques like flow and RNA-seq to generate high resolution data. You can also use high resolution imaging techniques like CODEX. Moving into high throughput and building predictive models is exactly where we want to go. Currently, we can generate 7500 organoids from a single donor and screen them in the thousands. We're working on building a ML pipeline along with automation so that we can screen in the hundreds of thousands if not more. Key to this though is that we have designed a platform that is amenable to this kind of automation and scale.

whymauri 5y ago
Oh wow, your upcoming plans sound great. Keep up the good work guys! And I highly recommend reaching out to a med chemist for some input. There's a lot of veteran retirees specializing in spaces adjacent to this who are open to consulting here and there. They're generally quite kind.
- rdifazio 5y ago
  Thank you! If you have a good recommendation, we'd love an introduction. Please let me know at robert at parallel.bio.