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And after the 3 doses the patient has immunity against HPV. Bloomberg: “A month after the third shot, 55% of those who got it developed antibody levels likely

And after the 3 doses the patient has immunity against HPV. Bloomberg: “A month after the third shot, 55% of those who got it developed antibody levels likely to provide significant protection.” Only 5% over half were “Likely” plus “significant” which is not definite by a long shot (no pun intended) https://www.bloomberg.com/news/articles/2021-08-11/third-moderna-shot-boosts-antibody-levels-in-transplant-patients https://www.bloomberg.com/news/articles/2021-08-11/third-mod...

maxerickson 5y ago
Are you expecting the results in people with compromised immune systems to generalize to the broader population? If so, why?
- josh_today 5y ago
  My point was equating a “multi dose defense shot” to a vaccine. After the immunocompromised have had the opportunity to protect themselves, the booster will be made available to all, just like the initial shots earlier this year. Those will be followed by another booster or more next year and so on.
  - phonon 5y ago
    Many vaccines don't have 100% efficacy, and diminished protection over time. The point is that if everyone has good enough protection from a vaccine, the outbreaks die down (r_0 < 1). For example, One dose of MMR vaccine is 93% effective against measles, 78% effective against mumps, and 97% effective against rubella. Two doses of MMR vaccine are 97% effective against measles and 88% effective against mumps. [1] [1] https://www.cdc.gov/vaccines/vpd/mmr/public/index.html#:~:text=One%20dose%20of%20MMR%20vaccine%20is,measles%20and%2088%25%20effective%20against%20mumps https://www.cdc.gov/vaccines/vpd/mmr/public/index.html#:~:te....
  - maxerickson 5y ago
    You are supposed to get a tetanus defense shot every 10 years too. The logic for a booster actually would be defense, it boosts antibodies which helps block more infections. An injection designed to modulate immune response by exposing the immune system to the target antigen is certainly a vaccine though.
belltaco 5y ago
Those are immunocompromised transplant patients. Basically when you get a transplant organ, the body's immune system tries to kill it so they have to use powerful drugs to kill off the immune system.

maxerickson 5y ago

Are you expecting the results in people with compromised immune systems to generalize to the broader population? If so, why?

josh_today 5y ago
My point was equating a “multi dose defense shot” to a vaccine. After the immunocompromised have had the opportunity to protect themselves, the booster will be made available to all, just like the initial shots earlier this year. Those will be followed by another booster or more next year and so on.
- phonon 5y ago
  Many vaccines don't have 100% efficacy, and diminished protection over time. The point is that if everyone has good enough protection from a vaccine, the outbreaks die down (r_0 < 1). For example, One dose of MMR vaccine is 93% effective against measles, 78% effective against mumps, and 97% effective against rubella. Two doses of MMR vaccine are 97% effective against measles and 88% effective against mumps. [1] [1] https://www.cdc.gov/vaccines/vpd/mmr/public/index.html#:~:text=One%20dose%20of%20MMR%20vaccine%20is,measles%20and%2088%25%20effective%20against%20mumps https://www.cdc.gov/vaccines/vpd/mmr/public/index.html#:~:te....
- maxerickson 5y ago
  You are supposed to get a tetanus defense shot every 10 years too. The logic for a booster actually would be defense, it boosts antibodies which helps block more infections. An injection designed to modulate immune response by exposing the immune system to the target antigen is certainly a vaccine though.

belltaco 5y ago

Those are immunocompromised transplant patients. Basically when you get a transplant organ, the body's immune system tries to kill it so they have to use powerful drugs to kill off the immune system.