3 ms·

If Pfizer wore off in 6-8 months what does it say about the next year? A big chunk of the population would have lost a sizable chunk of immunity no? Are we real

If Pfizer wore off in 6-8 months what does it say about the next year? A big chunk of the population would have lost a sizable chunk of immunity no? Are we really confident that global vaccination would be high at that point? I really wish US ordered, manufactured and donated a ton more to quash this thing

deleted 5y ago
[deleted]
jacquesm 5y ago
It did not so much wear off as that it simply doesn't protect as well against this new strain. It most likely still protects just fine against the alpha variant but that one has now been all but displaced.
- jimsimmons 5y ago
  Crazy that we can see the pure savagery of evolution right in front of us
  - jacquesm 5y ago
    The rate at which viruses reproduce is what allows you to see this, every biology freshman probably does the e-coli + arsenic experiment, it's a real eye opener as to how slow walking a treatment can actually create a resistant strain.
desmosxxx 5y ago
Is it wearing off or just reduced efficacy to begin with? My understanding is that dosing between the vaccines were all different
standardUser 5y ago
My understanding is that this is more about generating a robust immune response in the first place than about losing protection over time. There have been a lot of studies looking at third shots, at natural immunity combined with vaccines, and even at mixing vaccines. And the general idea is that there are ways to generate a more optimal immune response, and the vaccine courses given emergency authorization are probably not the best of all options. Researchers have yet to determine how long natural immunity lasts, and it may last for a very long time. Immunity from vaccines is expected to be at least as durable as natural immunity, though some studies have shown a slight decline in protection over months. But there are definitely no clear signs yet that an annual shot will be necessary.
- jimsimmons 5y ago
  Ah got it. I didn’t catch the nuance that the efficacy drop is specific to delta. I wrongly assumed that it was for all variants. Thanks!

deleted 5y ago

[deleted]

jacquesm 5y ago

It did not so much wear off as that it simply doesn't protect as well against this new strain. It most likely still protects just fine against the alpha variant but that one has now been all but displaced.

jimsimmons 5y ago
Crazy that we can see the pure savagery of evolution right in front of us
- jacquesm 5y ago
  The rate at which viruses reproduce is what allows you to see this, every biology freshman probably does the e-coli + arsenic experiment, it's a real eye opener as to how slow walking a treatment can actually create a resistant strain.

desmosxxx 5y ago

Is it wearing off or just reduced efficacy to begin with? My understanding is that dosing between the vaccines were all different

standardUser 5y ago

My understanding is that this is more about generating a robust immune response in the first place than about losing protection over time. There have been a lot of studies looking at third shots, at natural immunity combined with vaccines, and even at mixing vaccines. And the general idea is that there are ways to generate a more optimal immune response, and the vaccine courses given emergency authorization are probably not the best of all options. Researchers have yet to determine how long natural immunity lasts, and it may last for a very long time. Immunity from vaccines is expected to be at least as durable as natural immunity, though some studies have shown a slight decline in protection over months. But there are definitely no clear signs yet that an annual shot will be necessary.

jimsimmons 5y ago
Ah got it. I didn’t catch the nuance that the efficacy drop is specific to delta. I wrongly assumed that it was for all variants. Thanks!