3 ms·

I was really hopeful for Novavax. But recent news about manufacturing woes and US pulling funding is disappointing. The preliminary results looked great. Combi

I was really hopeful for Novavax. But recent news about manufacturing woes and US pulling funding is disappointing. The preliminary results looked great. Combined with low rate of side-effects and higher storage temp (2-8 C), it could have been a good 2nd (or 3rd) choice for the developing world. https://www.nih.gov/news-events/news-releases/us-clinical-trial-results-show-novavax-vaccine-safe-prevents-covid-19 https://www.nih.gov/news-events/news-releases/us-clinical-tr...

giantg2 5y ago
I would have loved a protein based option. I think there haven't been enough questions around the mRNA vaccine longterm potential impact. There are woefully few studies exploring the potential for autoimmune conditions. I find this especially troubling when using ones own cells to develop the spike protein. Normally the immune system codes off multiple proteins of the cell, but this would be a problem when the other cell proteins are legitimate. Basically, there are still more questions than answers in my mind. I just hope the national countermeasure compensation fund will be able to handle any potential fallout.
- Exmoor 5y ago
  Keep in mind, every single cold and flu you've ever had has used the same mRNA pathway to duplicate itself. Anyone reading this has had this happen in their body literally billions of times and will have it happen billions more. Is it just the single-protein aspect of it (compared to a full virus) that bothers you?
  - giantg2 5y ago
    It's a little different, right? So J&J uses modified adenovirus which acts more similarly to real life, in that it's using a DNA transcription process (that's where they think some error occur and causes clotting/stroke issues). Although they are also just making a protein that displays on the outside of the cell. A real virus will create copies of itself via a similar method. These copies are inside of the cell and later leave it. So it's mostly a concern that in one way we are targeting a spike protein on out own cell, but normally a virus would be complete and not be displayed as part of the cell wall. That's where I wonder if some people's immune system might code off of other normal proteins in addition to the spike. I would have thought there would at least have been a study about autoimmune antibody levels. I found one about severe covid patients having a higher likelihood of having them, but I couldn't find a study looking at the vaccines. It's pretty frustrating that I'm being downvoted for asking what I think is a legitimate question, one that apparently hasn't been looked into (since I can't find any study and the downvoters haven't provided one either).

giantg2 5y ago

I would have loved a protein based option. I think there haven't been enough questions around the mRNA vaccine longterm potential impact. There are woefully few studies exploring the potential for autoimmune conditions. I find this especially troubling when using ones own cells to develop the spike protein. Normally the immune system codes off multiple proteins of the cell, but this would be a problem when the other cell proteins are legitimate. Basically, there are still more questions than answers in my mind. I just hope the national countermeasure compensation fund will be able to handle any potential fallout.

Exmoor 5y ago
Keep in mind, every single cold and flu you've ever had has used the same mRNA pathway to duplicate itself. Anyone reading this has had this happen in their body literally billions of times and will have it happen billions more. Is it just the single-protein aspect of it (compared to a full virus) that bothers you?
- giantg2 5y ago
  It's a little different, right? So J&J uses modified adenovirus which acts more similarly to real life, in that it's using a DNA transcription process (that's where they think some error occur and causes clotting/stroke issues). Although they are also just making a protein that displays on the outside of the cell. A real virus will create copies of itself via a similar method. These copies are inside of the cell and later leave it. So it's mostly a concern that in one way we are targeting a spike protein on out own cell, but normally a virus would be complete and not be displayed as part of the cell wall. That's where I wonder if some people's immune system might code off of other normal proteins in addition to the spike. I would have thought there would at least have been a study about autoimmune antibody levels. I found one about severe covid patients having a higher likelihood of having them, but I couldn't find a study looking at the vaccines. It's pretty frustrating that I'm being downvoted for asking what I think is a legitimate question, one that apparently hasn't been looked into (since I can't find any study and the downvoters haven't provided one either).