Ask HN: What is the state-of-art in virtual DOM nowadays?

It's been a few years since I last looked into virtual DOMs to speed up web app perf. Have browsers solved these problems and there's no need for Virtual DOM layers any more? Are there new browser APIs I should be aware of? I now have a new simulation web app, where I'm often rendering 50,000 agents at once, with 1 agent === 1 dom element. I expect to target WebGL/Canvas in the future, but right now my thought was to push DOM to the limit. I've already sped things up multiples through standard profiling using Dev Tools Performance Tab, but while I do that I wanted to start another "thread" going where I look at state of the art ways of faster DOM updates. Is there some blazing fast tiny new virtual DOM only library I should look at?