4 ms·
> vaccines provide a stronger immune response than infection This is a blatant oversimplification & misrepresentation of the article you referenced, and the pa
by criticaltinker 5y ago
> vaccines provide a stronger immune response than infection
This is a blatant oversimplification & misrepresentation of the article you referenced, and the paper which it cites [1]. The paper makes no claims that vaccine induced immune responses are more or less superior than the immune response induced by natural infection.
Quote from [1]:
- "Specifically, antibodies elicited by the mRNA vaccine were more focused to the RBD compared to antibodies elicited by an infection, which more often targeted other portions of the spike protein."
Counterintuitively, this property of the current mRNA vaccines - the induction of an immune response highly targeted toward the spike protein RBD - when combined with compulsory mass vaccination, could result in widespread proliferation of vaccine resistant variants [2][3][4][5]. This is a serious concern that is on the radar of many top experts in the field.
The second and third order consequences of mass vaccination using an imperfect vaccine are anything but simple, and very much pose a public health risk.
When you consider the evidence supporting the fact that natural immunity is at least equally effective as vaccination (a few more supporting references here [6][7]), it becomes very difficult to defend the idea you're advocating:
> it's simple enough: pretty much everybody (over 12 until trials complete) should get vaccinated
[1] Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection
https://stm.sciencemag.org/content/13/600/eabi9915 https://stm.sciencemag.org/content/13/600/eabi9915
[2] Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein
https://pubmed.ncbi.nlm.nih.gov/33909660/ https://pubmed.ncbi.nlm.nih.gov/33909660/
[3] SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern
https://science.sciencemag.org/content/early/2021/06/30/science.abi7994 https://science.sciencemag.org/content/early/2021/06/30/scie...
[4] mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants
https://www.nature.com/articles/s41586-021-03324-6 https://www.nature.com/articles/s41586-021-03324-6
[5] Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens
https://journals.plos.org/plosbiology/article?id=10.1371%2Fjournal.pbio.1002198 https://journals.plos.org/plosbiology/article?id=10.1371%2Fj...
[6] Necessity of COVID-19 vaccination in previously infected individuals
https://www.medrxiv.org/content/10.1101/2021.06.01.21258176v3.full.pdf https://www.medrxiv.org/content/10.1101/2021.06.01.21258176v...
[7] Antibody Responses 8 Months after Asymptomatic or Mild SARS-CoV-2 Infection
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920668/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920668/