4 ms·

[1] is not generally supportive of your very broad statement. You must qualify you statement with some indication of this stated limitation: "carrying “single

[1] is not generally supportive of your very broad statement. You must qualify you statement with some indication of this stated limitation: "carrying “single letter” changes in a key portion of their spike protein"

_Microft 5y ago
I couldn't put the quote into context properly, so in case you are also wondering, here is the full quote: "The new evidence shows that protective antibodies generated in response to an mRNA vaccine will target a broader range of SARS-CoV-2 variants carrying “single letter” changes in a key portion of their spike protein compared to antibodies acquired from an infection.", excerpt from the article
- deleted 5y ago
  [deleted]
raphlinus 5y ago
It is one datapoint among many, but I found it interesting because it is based on careful biological experimentation and directly compares immune response from vaccination and prior infection. Another relevant quote: "Importantly, the vaccine-elicited antibodies targeted a broader range of places on the RBD than those elicited by natural infection." This is not an intuitively obvious result. But, since it was asked, here are more studies that support the broader point: * https://www.contagionlive.com/view/immune-response-from-mrna-covid-19-vaccines-is-more-robust-than-natural-infection https://www.contagionlive.com/view/immune-response-from-mrna... describes a study directly addressing the question, and with impressive results. * https://medicine.wustl.edu/news/covid-19-vaccine-generates-immune-structures-critical-for-lasting-immunity/ https://medicine.wustl.edu/news/covid-19-vaccine-generates-i... didn't directly compare against prior infection, but this is discussed briefly and there is strong support in favor of protection from vaccines. * https://www.medpagetoday.com/opinion/marty-makary/92434 https://www.medpagetoday.com/opinion/marty-makary/92434 is a discussion with a virologist (not peer reviewed science).
- peteradio 5y ago
  It seems odd to present these tangential measurements when what I think most people are interested in is personal outcomes. How can one relate relative increases in seropositivity to patient outcomes? Why don't we see studies which conclusively nail this down? I'm well aware of this study https://www.cdc.gov/mmwr/volumes/70/wr/pdfs/mm7032e1-H.pdf https://www.cdc.gov/mmwr/volumes/70/wr/pdfs/mm7032e1-H.pdf, I'm unmoved by it, see this comment: https://news.ycombinator.com/item?id=28106987 https://news.ycombinator.com/item?id=28106987 . Are you aware of more substantial studies to date? Thank you for the links and the discussion. I personally have yet to get the vaccine but do consider myself persuadable.

_Microft 5y ago

I couldn't put the quote into context properly, so in case you are also wondering, here is the full quote: "The new evidence shows that protective antibodies generated in response to an mRNA vaccine will target a broader range of SARS-CoV-2 variants carrying “single letter” changes in a key portion of their spike protein compared to antibodies acquired from an infection.", excerpt from the article

deleted 5y ago
[deleted]

raphlinus 5y ago

It is one datapoint among many, but I found it interesting because it is based on careful biological experimentation and directly compares immune response from vaccination and prior infection. Another relevant quote: "Importantly, the vaccine-elicited antibodies targeted a broader range of places on the RBD than those elicited by natural infection." This is not an intuitively obvious result. But, since it was asked, here are more studies that support the broader point: * https://www.contagionlive.com/view/immune-response-from-mrna-covid-19-vaccines-is-more-robust-than-natural-infection https://www.contagionlive.com/view/immune-response-from-mrna... describes a study directly addressing the question, and with impressive results. * https://medicine.wustl.edu/news/covid-19-vaccine-generates-immune-structures-critical-for-lasting-immunity/ https://medicine.wustl.edu/news/covid-19-vaccine-generates-i... didn't directly compare against prior infection, but this is discussed briefly and there is strong support in favor of protection from vaccines. * https://www.medpagetoday.com/opinion/marty-makary/92434 https://www.medpagetoday.com/opinion/marty-makary/92434 is a discussion with a virologist (not peer reviewed science).

peteradio 5y ago
It seems odd to present these tangential measurements when what I think most people are interested in is personal outcomes. How can one relate relative increases in seropositivity to patient outcomes? Why don't we see studies which conclusively nail this down? I'm well aware of this study https://www.cdc.gov/mmwr/volumes/70/wr/pdfs/mm7032e1-H.pdf https://www.cdc.gov/mmwr/volumes/70/wr/pdfs/mm7032e1-H.pdf, I'm unmoved by it, see this comment: https://news.ycombinator.com/item?id=28106987 https://news.ycombinator.com/item?id=28106987 . Are you aware of more substantial studies to date? Thank you for the links and the discussion. I personally have yet to get the vaccine but do consider myself persuadable.