So this makes it sound like we might be headed for semi-annual or even quarterly boosters. “one possible solution to the problem of immune evasion by SARS-CoV-

So this makes it sound like we might be headed for semi-annual or even quarterly boosters. “one possible solution to the problem of immune evasion by SARS-CoV-2 that has been proposed is to develop a new vaccine update every year, similar to influenza [42]. In practice, such a solution will only work in the face of a moderate pace of evolution of SARS-CoV-2 and a low degree of clonal diversity among various clades of SARS-CoV-2 as they evolve to evade the current crop of vaccines. Further, if within-host evolution of SARS-CoV-2 contributes to population-level immune evasion, the valley-crossing mechanism described in this paper could accelerate the emergence of vaccine-resistant strains in the months following vaccine deployment. To the extent that new strains of SARS-CoV-2 are antigenically distinct, this may also lead to increased risk of antibody-dependent enhancement (ADE), as one mechanism for ADE involves antibodies that bind to the pathogen but fail to neutralize it [43]. Finally, our work suggests that immune evasion requiring one to two mutations occurs within months, raising the prospect that this phenomenon will further shorten the duration of natural immunity, which is already limited by the relatively short duration of the humoral [44,45] and cellular [46] responses to SARS-CoV-2 infection. Further studies are required to understand the risk immune evasion poses to a strategy of annually updated vaccines.” I wonder if this is why Dr Fauci is emphasizing the need for therapeutics as higher priority than vaccines at this point? I should say though, mathematical biological models like the ones in this study are not something I feel very well equipped to evaluate. How often are such models wrong? What are the incentives for the company associated with these authors, “Fractal Therapeutics”? Obviously Harvard is Harvard, but I just can’t understand why smart people aren’t talking about this stuff. Murti-Bing pills?