4 ms·
See these peer-reviewed papers for some insight into the second and third order evolutionary dynamics that we face with the current spike protein focused mRNA v
by criticaltinker 5y ago
See these peer-reviewed papers for some insight into the second and third order evolutionary dynamics that we face with the current spike protein focused mRNA vaccines for SARS-CoV-2 [1][2].
These are serious long-term concerns, which may not manifest overnight, but they are certainly on the radar of many experts in the field.
[1] Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein
https://pubmed.ncbi.nlm.nih.gov/33909660/ https://pubmed.ncbi.nlm.nih.gov/33909660/
[2] SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern
https://science.sciencemag.org/content/early/2021/06/30/science.abi7994 https://science.sciencemag.org/content/early/2021/06/30/scie...
[3] Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens
https://journals.plos.org/plosbiology/article?id=10.1371%2Fjournal.pbio.1002198 https://journals.plos.org/plosbiology/article?id=10.1371%2Fj...