4 ms·

Just a few days ago there was a Twitter trending item insisting that people who have recovered from infection should still get vaccinated. My brother-in-law's d

Just a few days ago there was a Twitter trending item insisting that people who have recovered from infection should still get vaccinated. My brother-in-law's doctors told him he was actually at higher risk because of his prior infection and vaccination was even more important for him. I'm disgusted by the level of disinformation that's being used to push these shots. Here's a question: If subsequent vaccine doses reduce humoral and cellular immunity, which are the primary source of long-term protection in the Covid recovered, AND if the vaccines don't actually prevent infection, then are people who get boosters for each new variant just going to be tanking their own long-term immunity regardless of how many times they get infected and recover?

johntfella 5y ago
That is an excellent question, I hope someone studies this in the future. The best I can offer is this study on flu vaccines that seem to show that annual repeated uptake undermine CD4 cell response;"We find a striking disparity in their responses, with previously vaccinated subjects exhibiting significantly blunted CD4 T-cell responses and diminished antibody responses." (1) I know they are different viruses etc, but it is something to consider in light of the previous mentioned study and also all what seems to be going on with CDC. 1. https://doi.org/10.1093/infdis/jiz433 https://doi.org/10.1093/infdis/jiz433
- tguvot 5y ago
  there were recently covid19/monkeys/t-cell experiment. they depleted t-cells and infected monkeys. there wasn't much difference https://journals.asm.org/doi/10.1128/mBio.01503-21 https://journals.asm.org/doi/10.1128/mBio.01503-21
  - johntfella 5y ago
    "Neither primed CD4+ nor CD8+ T cells appeared critical for immunoglobulin class switching, the development of immunological memory, or protection from a second infection." this seems reasonable, it never made sense to me that one can not get reinfected. for depletion, it would seem then a counter to the second dose argument, yet again I revert back to my statement above that to me I'm positioned in that I can wait for the fog to clear a bit. A lot of this seems very early days in the Iraq war when the media and admin were in the same boat for the purpose of the invasion etc.
    - tguvot 5y ago
      second dose is to boost antibody levels (tcell also rise, but their effectiveness is... ) . but over the time they go down. third dose helps to boosts it way up https://i.ibb.co/2YJYSRK/226206675-10219822648699699-6602884157898127947-n.jpg https://i.ibb.co/2YJYSRK/226206675-10219822648699699-6602884...

johntfella 5y ago

That is an excellent question, I hope someone studies this in the future. The best I can offer is this study on flu vaccines that seem to show that annual repeated uptake undermine CD4 cell response;"We find a striking disparity in their responses, with previously vaccinated subjects exhibiting significantly blunted CD4 T-cell responses and diminished antibody responses." (1) I know they are different viruses etc, but it is something to consider in light of the previous mentioned study and also all what seems to be going on with CDC. 1. https://doi.org/10.1093/infdis/jiz433 https://doi.org/10.1093/infdis/jiz433

tguvot 5y ago
there were recently covid19/monkeys/t-cell experiment. they depleted t-cells and infected monkeys. there wasn't much difference https://journals.asm.org/doi/10.1128/mBio.01503-21 https://journals.asm.org/doi/10.1128/mBio.01503-21
- johntfella 5y ago
  "Neither primed CD4+ nor CD8+ T cells appeared critical for immunoglobulin class switching, the development of immunological memory, or protection from a second infection." this seems reasonable, it never made sense to me that one can not get reinfected. for depletion, it would seem then a counter to the second dose argument, yet again I revert back to my statement above that to me I'm positioned in that I can wait for the fog to clear a bit. A lot of this seems very early days in the Iraq war when the media and admin were in the same boat for the purpose of the invasion etc.
  - tguvot 5y ago
    second dose is to boost antibody levels (tcell also rise, but their effectiveness is... ) . but over the time they go down. third dose helps to boosts it way up https://i.ibb.co/2YJYSRK/226206675-10219822648699699-6602884157898127947-n.jpg https://i.ibb.co/2YJYSRK/226206675-10219822648699699-6602884...