3 ms·
A good point, but antibody sequestration isn't how they explained the vaccine's actions. Instead it's that the cocaine-antibody complex is too large to cross th
by skue 15y ago
A good point, but antibody sequestration isn't how they explained the vaccine's actions. Instead it's that the cocaine-antibody complex is too large to cross the blood-brain barrier.
So it's unclear whether the antibody response (which the study showed was limited) would sequester the cocaine enough to eliminate its systemic effects.
- Daniel_Newby 15y ago... the cocaine-antibody complex is too large to cross the blood-brain barrier. If the cocaine were weakly bound, it would spend part of its time detached from the antibodies, and during those times be able to enter the brain in the usual way. Since the antibodies have a large effect on the psychological effect-response curve, the binding must be quite strong. Therefore cocaine is sequestered throughout the body.