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> Not one of the 1359 previously infected subjects who remained unvaccinated had a SARS-CoV-2 infection over the duration of the study. In a Cox proportional ha
by nanis 5y ago
> Not one of the 1359 previously infected subjects who remained unvaccinated had a SARS-CoV-2 infection over the duration of the study. In a Cox proportional hazards regression model, after adjusting for the phase of the epidemic, vaccination was associated with a significantly lower risk of SARS-CoV-2 infection among those not previously infected (HR 0.031, 95% CI 0.015 to 0.061) but not among those previously infected (HR 0.313, 95% CI 0 to Infinity).
> Conclusions Individuals who have had SARS-CoV-2 infection are unlikely to benefit from COVID-19 vaccination, and vaccines can be safely prioritized to those who have not been infected before.
- criticaltinker 5y agoNice concise summary - It's worth noting this publication does not appear to have been peer-reviewed yet. That said, the relatively large sample size (52238 Employees of the Cleveland Clinic Health System) provides strong statistical power, which should give the results serious credibility. If these results hold (ie there are no systematic errors in their design or analysis), the next logical step would appear to be a similar analysis which accounts for newer variants of concern (eg delta). Is anyone aware of such publications?