Might not an effective approach be the opposite of this vaccine? Rather than trying to down-modulate the effects of (addictive substance here), if you instead u

Might not an effective approach be the opposite of this vaccine? Rather than trying to down-modulate the effects of (addictive substance here), if you instead up-modulate undesirable effects, then even a small dose would have less pleasure than before. Disulfiram (Antabuse) seems to be mentioned a lot in this thread, and that intuitively seems like a saner approach than "make it so they need more to get the same high".