3 ms·

It's obvious we need booster vaccinations. But not another intramuscular that only seeps in serum IgG antibodies into the lower lungs. The levels of antibodies

It's obvious we need booster vaccinations. But not another intramuscular that only seeps in serum IgG antibodies into the lower lungs. The levels of antibodies in the upper respiratory mucosa are never very high and drop rapidly. Viral infection of the mucosa and shedding still occurs. We need operation warp speed type money for funding the two good intranasal sars-cov-2 vaccine trials going on right now and to start more. Intranasal vaccination after intramuscular will recruit and specialize B and T cells to the upper respiratory mucosa and establish IgA antibodies resident for long periods there. Being intranasally vaccinated after intramuscular could actually stop the spread and end the pandemic. edit: btw, all this has been known about aerosol spread respiratory viruses and human physiology since the 1960s.

loceng 5y ago
This same conversation has been trying to be had for existing medication Ivermectin, except little money to be made with it so the industry has been suppressing it and dismissing it nudging government institutions, who seem to rely on what pharma says, to also dismiss/ignore it.
- deleted 5y ago
  [deleted]
- myko 5y ago
  Actually, no, there just isn't evidence that ivermectin (or hydroxychloroquine before it) are effective at combatting COVID-19. There is a lot of evidence that the vaccines are good at combatting COVID-19 though. https://www.fda.gov/consumers/consumer-updates/why-you-should-not-use-ivermectin-treat-or-prevent-covid-19 https://www.fda.gov/consumers/consumer-updates/why-you-shoul... Where did you first hear about using this drug to combat COVID-19, and did they describe the mechanism by which this parasite killing drug would combat the virus?
  - loceng 5y ago
    What's your source refuting all of these studies - c19ivermectin.com ? + Ivermectin mechanism: https://www.sciencedirect.com/science/article/pii/S0166354220302011#:~:text=Ivermectin%20binds%20to%20and%20destabilises,normal%2C%20more%20efficient%20antiviral%20response https://www.sciencedirect.com/science/article/pii/S016635422.... Quick Google search finds that.
    - myko 5y ago
      In vitro, and studies are underway to determine if it would be effective in people. As such, it is not recommended in any way to use currently to treat or prevent COVID-19, and can be dangerous - as mentioned in the FDA link I shared above. The site you mention above has been debunked as a credible source of study information, and is truly disinformation: https://ebm.bmj.com/content/early/2021/05/26/bmjebm-2021-111678 https://ebm.bmj.com/content/early/2021/05/26/bmjebm-2021-111...
standardUser 5y ago
It is not obvious we need booster vaccinations. There's simply not enough data yet to call this "obvious". Even "likely" is a stretch. Time will tell how long effective immunity lasts, but we absolutely do not know that number yet. EDIT: To be fair, it is at least likely that high-risk individuals may need boosters. Israel is already distributing them. But the idea that we will need an annual COVID shot, or that most people will need any additional shots at all, is entirely speculative. The annual shot idea is especially dubious because I think people infer this from the flu, which mutates far more rapidly than this coronavirus.
- beebmam 5y ago
  That's correct, so far. It appears that humans who have been vaccinated with an mRNA vaccine still have a strong immune response to Delta variant. In fact, far better of an immune response than people who were infected with a previous variant. Source is MedCram, easily the best source of medical information on YouTube, specifically at 7:05: https://www.youtube.com/watch?v=5RWGh19yTXw https://www.youtube.com/watch?v=5RWGh19yTXw
  - superkuh 5y ago
    I am not in any way saying the intramuscular do not protect the internal body tissues against variants. I am saying that it's important to protect against mucosa infection too to prevent spread and that requires intranasal vaccination.
- nicoburns 5y ago
  Effective immunity against current variants isn't too likely to be an issue, but new variants that circumvent that immunity seem pretty likely to me seeing as we're already seeing this to some extent with the Delta variant and we're nowhere near suppressing case levels to the point that we'd slow new variants from emerging.
- tdhz77 5y ago
  Big pharma is pushing for boosters before the science. I’m happy that even Congress was skeptical of the claim in the last covid congressional committee discussion.
lmilcin 5y ago
You seem to have a bunch of knowledge on the subject. Can you explain where you have this knowledge from and maybe explain a little bit more? For example I wasn't even aware that actual method of vaccination makes any difference and I don't understand how or why exactly. I just thought we inject into muscle purely because it is convenient and maybe because it would not survive trip through digestive tract.

loceng 5y ago

This same conversation has been trying to be had for existing medication Ivermectin, except little money to be made with it so the industry has been suppressing it and dismissing it nudging government institutions, who seem to rely on what pharma says, to also dismiss/ignore it.

deleted 5y ago
[deleted]
myko 5y ago
Actually, no, there just isn't evidence that ivermectin (or hydroxychloroquine before it) are effective at combatting COVID-19. There is a lot of evidence that the vaccines are good at combatting COVID-19 though. https://www.fda.gov/consumers/consumer-updates/why-you-should-not-use-ivermectin-treat-or-prevent-covid-19 https://www.fda.gov/consumers/consumer-updates/why-you-shoul... Where did you first hear about using this drug to combat COVID-19, and did they describe the mechanism by which this parasite killing drug would combat the virus?
- loceng 5y ago
  What's your source refuting all of these studies - c19ivermectin.com ? + Ivermectin mechanism: https://www.sciencedirect.com/science/article/pii/S0166354220302011#:~:text=Ivermectin%20binds%20to%20and%20destabilises,normal%2C%20more%20efficient%20antiviral%20response https://www.sciencedirect.com/science/article/pii/S016635422.... Quick Google search finds that.
  - myko 5y ago
    In vitro, and studies are underway to determine if it would be effective in people. As such, it is not recommended in any way to use currently to treat or prevent COVID-19, and can be dangerous - as mentioned in the FDA link I shared above. The site you mention above has been debunked as a credible source of study information, and is truly disinformation: https://ebm.bmj.com/content/early/2021/05/26/bmjebm-2021-111678 https://ebm.bmj.com/content/early/2021/05/26/bmjebm-2021-111...

standardUser 5y ago

It is not obvious we need booster vaccinations. There's simply not enough data yet to call this "obvious". Even "likely" is a stretch. Time will tell how long effective immunity lasts, but we absolutely do not know that number yet. EDIT: To be fair, it is at least likely that high-risk individuals may need boosters. Israel is already distributing them. But the idea that we will need an annual COVID shot, or that most people will need any additional shots at all, is entirely speculative. The annual shot idea is especially dubious because I think people infer this from the flu, which mutates far more rapidly than this coronavirus.

beebmam 5y ago
That's correct, so far. It appears that humans who have been vaccinated with an mRNA vaccine still have a strong immune response to Delta variant. In fact, far better of an immune response than people who were infected with a previous variant. Source is MedCram, easily the best source of medical information on YouTube, specifically at 7:05: https://www.youtube.com/watch?v=5RWGh19yTXw https://www.youtube.com/watch?v=5RWGh19yTXw
- superkuh 5y ago
  I am not in any way saying the intramuscular do not protect the internal body tissues against variants. I am saying that it's important to protect against mucosa infection too to prevent spread and that requires intranasal vaccination.
nicoburns 5y ago
Effective immunity against current variants isn't too likely to be an issue, but new variants that circumvent that immunity seem pretty likely to me seeing as we're already seeing this to some extent with the Delta variant and we're nowhere near suppressing case levels to the point that we'd slow new variants from emerging.
tdhz77 5y ago
Big pharma is pushing for boosters before the science. I’m happy that even Congress was skeptical of the claim in the last covid congressional committee discussion.

lmilcin 5y ago

You seem to have a bunch of knowledge on the subject. Can you explain where you have this knowledge from and maybe explain a little bit more? For example I wasn't even aware that actual method of vaccination makes any difference and I don't understand how or why exactly. I just thought we inject into muscle purely because it is convenient and maybe because it would not survive trip through digestive tract.