3 ms·
> IIUC the folding and unfolding pathways of a protein are not time reversed wrt each other. That's more or less correct, but in my proposal, we are not modeli
by dnautics 5y ago
> IIUC the folding and unfolding pathways of a protein are not time reversed wrt each other.
That's more or less correct, but in my proposal, we are not modeling the folding pathway of a protein. One way to think of it: we would be modelling the reverse unfolding pathway of a protein in a universe with different (simpler) physics than ours, physics in which (hopefully) the time reversed unfolding pathway yields the correctly folded protein in OUR universe.
- d110af5ccf 5y agoYour description kind of reminds me of the 2018 World Models publication. Are you familiar with that work and/or am I off base? (https://worldmodels.github.io/ https://worldmodels.github.io/) (https://arxiv.org/abs/1803.10122 https://arxiv.org/abs/1803.10122)
- dnautics 5y agoOff base. I'm using universes as a florid description of the fact that our QM models are crap but they might be useful of the laws of physics were different.