I haven't had to do anything fancy yet. I just install both and try to find the MacPorts equivalent first before using Homebrew. For example, I use the MacPor

I haven't had to do anything fancy yet. I just install both and try to find the MacPorts equivalent first before using Homebrew. For example, I use the MacPorts version of Python. If I need any Python dependencies I install them either via MacPorts or pip. In fact, I only have two Homebrew packages installed: dockutil and mas. Both are tools I use as part of ansible scripts which don't have MacPorts equivalents. All the remaining Homebrew packages are all cask apps (Firefox, Chrome, Discord, Slack, etc.). Those don't have any dependencies that would cause any conflicts. For comparison, I have 139 MacPorts packages installed. 2 Homebrew packages, and 21 Homebrew cask apps.